Abundant evidence has suggested that neuroinflammation participates in the pathogenesis of Parkinson's disease (PD). The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising therapeutic target. Ganoderma lucidum (GL), a traditional Chinese medicinal herb, has been shown potential neuroprotective effect in our clinical trials that lead us to speculate that it might possess potent anti-inflammatory and immunomodulating properties. To test this hypothesis, the present study investigated the potential neuroprotective effect of GL and underlying mechanism through inhibiting microglial activation using co-cultures of dopaminergic neurons and microglia. The cultures of microglia or MES23.5 cells alone or together were treated for 24 h with lipopolysaccharide (LPS, 0.25 μg/mL) as a positive control, GL extracts (50-400 μg/mL) or MES23.5 cell membrane fragments (150 μg/mL) were used in treatment groups. Microglia activation, microglia-derived harmful factors and [(3)H]dopamine ([(3)H]DA) uptake of MES23.5 cells were analyzed. The results showed that microglia were activated by LPS and MPP(+)-treated MES23.5 cell membrane fragments, respectively. Meanwhile, GL extracts significantly prevented the production of microglia-derived proinflammatory and cytotoxic factors, including nitric oxide, tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β), in a dose-dependent manner and down-regulated the TNF-α and IL-1β expressions on mRNA level. In addition, GL extracts antagonized the reduction of [(3)H]DA uptake induced by MPP(+) and microglial activation. In conclusion, these results suggest that GL may be a promising agent for the treatment of PD through anti-inflammation.
Ganoderma or red Reishi Spore might help to improve your health. Its biggest medical benefit is the way it strengthens your immune system. It can be considered a preventative medicine instead of a treatment for a certain disease.
Ganoderma Spore makes sense due to its ability to improve the function of the immune system. It is said to help the body adapt to many types of body stresses such as trauma, sleep deprivation, temperature, exposure to toxins, psychological stress, infection, or radiation. It helps the organisms in the body return to a normal, balanced state after illness.
Red Reishi or Ganoderma Spore, acts as regulator that fine-tunes our immune systems. Its main purpose is to detect pathogens such as bacteria and other viruses that attack the body.
A compromised immune system can develop viruses, parasites, bacteria and fungi that cause disease. Repeated use of common antibiotics, anti-viral agents, and anti-fungal medications can cause microbes to develop a resistance to the medications. Consuming red Reishi can eliminate these problems. It's gaining popularity among many as an adjunct to combating the disagreeable side effects of radiation and chemotherapy associated with cancer treatment.
Red Reishi has exceptional anti-stress qualities that can help improve memory, reduce tension and sharpen your concentration. It is particularly helpful in the treatment of degenerative diseases, such as Alzheimer's and dementia that affects the elderly.
Ganoderma or Reishi has been around for many centuries. Originally consumed by emperors and royalty as the miracle herbs, many westerners have overlooked it until recently.
Some of the many health benefits of Ganoderma are its antioxidant effects on the body, the positive effects on circulatory system and respiratory tract. It has been shown to lower high blood pressure, balance cholesterol levels and reduce the symptoms of bronchitis, asthma and other lung problems.
Scientist have studied Ganoderma Spore's use as a treatment for cancer, insomnia, arthritis, Parkinson's disease, and many other diseases.
Used for years in Japan and China as a licensed medical treatment, Reishi is often used for its calming and sedative effects. Research among United States, UK, China and Japan prove the unparalleled benefits of this miracle mushroom when used in healing and holist health.
So what exactly is Ganoderma? Ganoderma Lucidum is the scientific name for a species of red mushroom also called reishi that is cultivated and grown wild in China and Asia for thousands of years. The reishi mushroom has been expensive and hard to find in large quantities until recently. The Reishi mushroom only grows on one specific tree in Asia. Scientist are now cultivating the mushroom indoors. This mushroom has more than 200 active elements known to improve health.
Some other benefits of using or drinking Ganoderma Spore are:
Balances blood sugar levels and pancreatic functions.
Protects against skin cell degeneration, improving skins texture and reducing appearance of aging
Eliminates toxins accumulated in the body
Increases metabolism
Reduces fatigue
Contains anti-oxidants that inhibit damaging free radicals
Helps unclog arteries and supports liver function
Boosts energy
Improves the digestive system
Relieves sinus congestion and other respiratory problems
Rejuvenates body tissues and cells
Boost all body functions
Beautifies the skin by improving vitality
Effectively aids in the healing of skin wounds, scrapes, psoriasis, mouth ulcers, external bleeding, bug bits and stings "